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Similarly, network pharmacology uncovered the molecular basis by which the natural compound 2ʹ-hydroxychalcone ameliorates copper sulfate-induced inflammation in zebrafish (Shen et al., 2025), and clarified how Moutan Cortex ( Paeonia suffruticosa ) exerts its anti-inflammatory and blood-activating effects via modulation of the coagulation–inflammation cascade—a mechanism validated across cellular, rat, and zebrafish models